Eastern Sicily is one of the best road trip.
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A Sicily, Italy Itinerary—10 Day Road Trip!

Eastern Sicily is a stunning region offering everything from ancient temples and Baroque churches to beautiful beaches and some of the best food in Italy. With this 10-day itinerary, you’ll get a taste of it all while keeping a relaxed, “Sicilian” pace. Here’s how to spend 10 days exploring the highlights of Eastern Sicily by car.

1. Arrive in Catania

Explore Catania on a Sicily road trip.
Catania is an ancient port city on Sicily’s east coast.

After arriving in Catania, visit the famous fish market and Elephant Square. Then, head to the mountain town of Nicolosi to stay for two nights. If you’re adventurous, try the nearby Monti Rossi Adventure Park before enjoying a dinner at local restaurants like Antico Orto dei Limoni or Osteria Garibaldi.

Accommodation in Nicolosi for the Next Two Nights:

For a budget hotel in Nicolosi, you can check out B&B La Porta Dell’Etna on Booking.

For a mid-range hotel in Nicolosi, you can check out Hotel Alle Pendici Dell’Etna on Booking.

2. Mount Etna

Towering over the eastern Sicily, Mount Etna is one of the world's most iconic volcanoes.
Mount Etna is an active volcano in Eastern Sicily. It is the tallest active volcano in Europe.

Explore Mount Etna, the largest active volcano in Italy, by hiking the Schiena dell’Asino trail or visiting the Silvestri Crateri. After your hike, treat yourself to a wine tasting and multi-course agriturismo meal at Murgo Winery. If it’s not Sunday, visit for dinner instead and savor Sicily’s finest wines.

3. Taormina

Explore Taormina during your Sicily road trip.
Taormina, while traveling Sicily by car.

Visit Taormina, known for its stunning Teatro Greco and breathtaking views of Mount Etna. Walk down Corso Umberto and grab granita at Bam Bar, the best in town. Enjoy the sea views at Piazza XI Aprile and explore the beautiful Villa Comunale Gardens.

Accommodation in Cefalu for the Next two Nights:

For a budget hotel in Cefalu, you can check out Casanova Bed & Breakfast Cefalu on Booking.

For a mid-range hotel in Cefalu, you can check out Hotel Kalura on Booking.

4. Cefalu

Include Cefalu during your Sicily itinerary 7 days.
Cefalu is one of the charming villages to explore Sicily by car.

Spend the day relaxing on Cefalu’s beautiful sandy beach, renting a chair at one of the many lidos. Wander around town, explore the old Roman baths, and grab dinner at local favorites like Tivitti or Al Gabbiano for an authentic Sicilian meal.

5. Turkish Steps

Your 10 days in Sicily by car.

Visit the Scala dei Turchi, or Turkish Steps, a white marl cliff near Realmonte. The cliff has been naturally weathered into “steps,” creating a beautiful natural attraction. Bring your bathing suit, but the beach may have seaweed—still, the stunning view is worth it.

Accommodation in Agrigento for the Next Two Nights:

For a budget hotel in Agrigento, you can check out Terrazza sul Rabato on Booking.

For a mid-range hotel in Agrigento, you can check out Le Cinque Novelle on Booking.

6. Agrigento

Agrigento is a must visit during your Sicily itinerary.
Eastern Sicily’s most famous and historic sites lie in Agrigento.

Explore the Valley of the Temples in Agrigento, featuring seven ancient Greek temples, including the well-preserved Tempio di Concordia. Arrive early to avoid the heat and bring plenty of water for your walking tour through this historical site.

7. Ragusa

Include Ragusa on your Sicily itinerary.
Ragusa is one of the most beautiful destinations you visit during your Sicily road trip.

Visit Ragusa Ibla, a stunning Baroque town and UNESCO World Heritage Site. Stroll through the streets to the Duomo di San Giorgio, enjoy local ice cream at Gelati Divini, and soak in the views from the top of the cliff overlooking the city.

Accommodation in Ragusa for the Next Two Nights:

For a budget hotel in Ragusa, you can check out Sizilien B&B on Booking.

For a mid-range hotel in Ragusa, you can check out Casa Vacanza B&B Sangiovanni on Booking.

8. Modica

Modica is a beautiful base to visit eastern Sicily.
Modica is an attractive historic town in Eastern Sicily.

Famous for its unique chocolate, Modica is a must-visit for food lovers. Take a chocolate tour and sample the grainy, cold-processed chocolate. Afterward, explore the town and visit the impressive Chiesa di San Giorgio.

9. Ortigia

Explore Ortigia in Eastern Sicily.
Sicily by car is the best way to see it.

Ortigia is the historical heart of Siracusa, connected by bridges to the mainland. Explore the bustling market, see the remains of the Temple of Apollo, and don’t miss the Duomo di Siracusa, which beautifully blends ancient history with Baroque architecture.

Accommodation in Ortigia for the Next Two Nights:

For a budget hotel in Ortigia, you can check out Il Mare di Ortiga on Booking.

For a mid-range hotel in Ortigia, you can check out Atrio B&B on Booking.

10. Siracusa

Siracusa is one of the most beautiful destinations during your Sicily road trip.
10 days in Sicily isn’t enough but hopefully, you’ll come back soon!

End your trip in Siracusa by visiting the Parco Archeologico Della Neapolis. See the impressive Greek theater, Roman theater, and the Ear of Dionysius. Alternatively, you can relax at a nearby beach before heading to the airport in Catania.

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READ THE FULL GUIDE: 10 Days Sicily Itinerary Road Trip—Picture Perfect Places & Pizza (Italy)

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